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Today, we enter happily into the secret world (as far as NICE is concerned) of SGLT2 inhibitors. These clever drugs increase glucose excretion by the kidney thereby reducing blood glucose levels. When manufacturers produce new drugs they have to show, … Continue reading

As long as manufactured goods have been around, “me-too” preparations have been around.  When a successful thing is introduced, competitors produce a similar one, but sufficiently different not to infringe patent laws. When Renault introduced the first people carrier, the … Continue reading

It is difficult to remember any time in the past when the British Medical Journal has withdrawn information in any articles it has published and yet this has now happened in the case of two articles on statins.  It turns … Continue reading

One of our friends is in the terminal phase of cancer. He was suffering quite a lot of pain so he was seen by one of the truly wonderful MacMillan Nurses. The nurse decided to give the pain killer in … Continue reading

“An MP’s Committee has warned that drugs companies routinely withhold results of clinical trials from doctors, leaving them poorly informed about how to treat patients” This report from the Public Accounts Committee arose as a result of the Department of … Continue reading

The long term management of COPD has been affected by the latest “me-too” drug to be announced.  Until now the only long-acting anti-muscarinic drug available was tioptropium. Until now, Boehringer-Ingelheim have had this important field to themselves.  But now, Almirall … Continue reading

People interested in diabetes are always talking about eyes, feet or kidneys. At the present time, the interest is in kidneys. That’s not to say that eyes and feet have taken a back seat. It’s just that a new treatment … Continue reading

The recent impact of the long trial on the benefits of HRT has again rasied the whole  question of clinical trials. The report: “Schierbeck LL, Rejnmark L, Tofteng CL et al, Effect of hormone replacement therapy on cardiovascular events in … Continue reading

Few if any things have had such a pharmaceutical roller-coaster ride than Hormone Replacement Therapy (HRT).  Let’s just look at the last 15 years. In the mid- to late nineties, HRT was the flavour of the month.  Eminent writers, such … Continue reading

Years ago someone produced a facetious (and fictional) history of a new drug.  It went something like this. 1.    New drug announced (“must try it” say all the whizz GP’s) 2.    Drug cures everything (No 1 best seller) 3.    Case … Continue reading

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