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Since the SGLT-2 inhibitors have been launched there have been studies that have suggested potential concerns such as ketoacidosis and amputation and those that have demonstrated positive benefits on cardiovascular outcomes. This meta-analysis of the drugs may dispel the anxieties … Continue reading

Today, we enter happily into the secret world (as far as NICE is concerned) of SGLT2 inhibitors. These clever drugs increase glucose excretion by the kidney thereby reducing blood glucose levels. When manufacturers produce new drugs they have to show, … Continue reading

As long as manufactured goods have been around, “me-too” preparations have been around.  When a successful thing is introduced, competitors produce a similar one, but sufficiently different not to infringe patent laws. When Renault introduced the first people carrier, the … Continue reading

For many years, conditions were treated and doctors did not really know whether they were achieving anything. Doctors tried to achieve good glycaemic control in people with diabetes without really knowing whether anything was being achieved. It was not until … Continue reading

It is difficult to remember any time in the past when the British Medical Journal has withdrawn information in any articles it has published and yet this has now happened in the case of two articles on statins.  It turns … Continue reading

We often seem to end up in Primary Care talking about what are often known as “trade-offs”. That is balancing the beneficial effects of drugs against possible harms due to side-effects. There are even ways of measuring them in the … Continue reading

One of our friends is in the terminal phase of cancer. He was suffering quite a lot of pain so he was seen by one of the truly wonderful MacMillan Nurses. The nurse decided to give the pain killer in … Continue reading

“An MP’s Committee has warned that drugs companies routinely withhold results of clinical trials from doctors, leaving them poorly informed about how to treat patients” This report from the Public Accounts Committee arose as a result of the Department of … Continue reading

If ever there was a “wonder drug”, then a statin would have a good chance of being called by such a name.  New guidance from America suggests that even more people would benefit from taking a statin than ever before. … Continue reading

Doctors have known for years that soluble (effervescent) preparations of drugs such as paracetamol contain quite high levels of salt.  They assumed, wrongly as it turns out, that patients did not take enough of the drugs to cause a problem. … Continue reading

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